Harvard Medical School: From restoration of youthful function in mouse models, to encouraging nonhuman-primate results, to an FDA-cleared first-in-human safety trial.
Dr. George Church, an AgeMeter Science Advisor, and Dr. David Sinclair were among the authors of a peer-reviewed Nature study that reported that partial epigenetic reprogramming restored youthful molecular patterns, promoted nerve regeneration, and reversed age-related vision loss in mouse models..
A Cell study led by Dr. David Sinclair and colleagues showed that controlled loss of epigenetic information caused aging-like changes across the bodies of mice, affecting multiple tissues and physiological, cognitive, and molecular measures. OSK reprogramming restored youthful epigenetic marks in tested cells and tissues, supporting the conclusion that loss of epigenetic information is a reversible cause of aging.
Life Biosciences, co-founded by Dr. David Sinclair, reported that the same OSK approach reached retinal cells and reduced loss of visual function and nerve fibers in a nonhuman-primate model of an age-related optic neuropathy—an important bridge toward human research.
The FDA cleared Life Biosciences’ Investigational New Drug application for ER-100, permitting a Phase 1 first-in-human trial focused on safety and tolerability in age-related optic neuropathies. This is permission to test—not FDA approval of the therapy.
Read the evidence: 2020 Nature study → 2023 Cell study → Nonhuman-primate findings → FDA IND clearance announcement → Clinical trial record →
For personal use
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Measure your functional biological age at home and follow your results over time with a guided individual experience.
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For healthcare & wellness practices
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Our history
AgeMeter carries forward more than three decades of work making functional biological age measurable, understandable, and useful.
1990–2011 — A pioneering functional-age system. Introduced in 1990, the H-SCAN Functional Age Test helped pioneer the measurement of functional biological age. Rather than relying on a single laboratory marker, it assessed multiple aspects of physiological and performance function. H-SCAN was presented at the first American Academy of Anti-Aging Medicine conference and was used by longevity-focused professionals for more than two decades. The complete system sold for $23,750.
Centers For Age Control — Worldwide dealer and sole distributor. Centers For Age Control Inc. became an H-SCAN worldwide dealer and later its sole distributor. This direct involvement provided extensive experience with the system, its functional-age principles, its professional users, and the practical requirements of conducting standardized assessments.
The transition — How AgeMeter began. When the H-SCAN inventor semi-retired and discontinued the system, he encouraged AgeMeter founder Elliott Small to develop a modern successor. The objective was to preserve the value of multi-biomarker functional-age measurement while replacing specialized legacy equipment with contemporary internet and touchscreen technology.
Harvard Medical School — Elliott Small and Dr. George Church. The transition was further facilitated by Small’s discussions with Dr. George Church at Harvard Medical School. Dr. Church said: "We've got to bring that H-SCAN Back!" Those discussions helped move the proposed modern successor forward as AgeMeter, connecting H-SCAN’s functional-age foundation with contemporary aging research and technology. That work became AgeMeter: a video guided, noninvasive platform designed to make functional biological-age assessment more accessible to individuals and healthcare practices. AgeMeter has also been exhibited at American Academy of Anti-Aging Medicine events.
A different lens on biological aging
Epigenetic and laboratory tests examine molecular signals. AgeMeter measures performance: what your body can do today. Using both can provide complementary views of aging and change over time.
AgeMeter calculations use versioned, research-based reference data for its functional biomarkers.
The tests measure different aspects of biological aging, so their results should be interpreted as complementary rather than interchangeable.
Professor of Genetics at Harvard Medical School and Professor of Health Sciences and Technology at Harvard and MIT. Member of the National Academy of Sciences, recipient of the Franklin Institute Bower Award for Achievement in Science for contributions to DNA sequencing. Other Recipients include Einstein and the Curies. He was named to the TIME 100 in the Titan category.
Investor and psychologist; President of the Hong Kong Association of Psychology; Vice President of the Hong Kong Society of Counseling and Psychology; and a Chartered Psychologist of the British Psychological Society. Creator of Psychological Compass and Brain Reset supplements, with experience advancing biofeedback stress research.
Board member and former President of the Massachusetts Medical Society, publisher of The New England Journal of Medicine, where he also served as a technology advisor. Affiliated with Tufts University School of Medicine.
Earned a BA from Yale University and an MBA from the Wharton School. Former Associate at McKinsey & Company and former Director of Enterprise Product and Experience Strategy at The Home Depot.
Biochemical Sciences graduate at Harvard College. Inventor on seven patents: four concerning aging-reversal methods and compositions and three concerning rapid battery charging. Former Kraft Foods chemist and computer programmer.
Harvard College and Tulane University School of Medicine graduate with postgraduate training at Harvard Medical School. Medical Director of gastroenterology and nutrition clinics in Atlanta. Helped establish, and became the first director of, the Clinical Division at Morehouse School of Medicine.
Technology Delivery Management Director at CCI in Atlanta. Earned a BS in Computer Science from Morehouse College.
Senior Program Manager at Microsoft and inventor on four patents. Earned BS and MS degrees in Computer Science from the Georgia Institute of Technology.
